World Covid Meter 9th March February 2021

Acute manageable immunogenic thrombogenic inflammatory contagious novel viral disease pandemic

 Novel Covid 19 viral vaccines

B 1.1.7 UK,  B.1.351 South Africa, P1 Brazil

Dr KK Aggarwal

President CMAAO, HCFI and Past National President IMA

Cases:1M: April 2, 2 M April 15, 3 M: April 27, 4 M May 8; 5 M 20 May, 6 M 30th May, 7 M 7th June, 8M by 15 June, 9 M 22nd June, 10 M 29th June. 11 M 4th July, 16 M , 17 M 29 July, 18 M 1st August, 21 .8 M 16 August, 25 M 30th August, 28 M 10 September,

Ground Zero: Wuhan in live animal market or cafeteria for animal pathogens: 10th January; Total cases are based on RT PCR, 67% sensitivity

B.1.1.7 lineage (a.k.a. 20I/501Y.V1 Variant of Concern (VOC) 202012/01): 23 mutations:  This variant has a mutation in the receptor binding domain (RBD) of the spike protein at position 501, where the amino acid asparagine (N) has been replaced with tyrosine (Y). The shorthand for this mutation is N501Y. This variant also has several other mutations, including: 69/70 deletion: occurred spontaneously many times and likely leads to a conformational change in the spike protein; P681H: near the S1/S2 furin cleavage site, a site with high variability in coronaviruses. This mutation has also emerged spontaneously multiple times; variant is associated with increased transmissibility (i.e., more efficient and rapid transmission); In January 2021, scientists from UK reported evidence[1] that suggests the B.1.1.7 variant may be associated with an increased risk of death compared with other variants; Early reports found no evidence to suggest that the variant has any impact on the severity of disease or vaccine efficacy.

B.1.351 lineage (a.k.a. 20H/501Y.V2): This variant has multiple mutations in the spike protein, including K417N, E484K, N501Y. Unlike the B.1.1.7 lineage detected in the UK, this variant does not contain the deletion at 69/70. This variant was first identified in Nelson Mandela Bay, South Africa, in samples dating back to the beginning of October 2020, and cases have since been detected outside of South Africa, including the United States. There is some evidence to indicate that one of the spike protein mutations, E484K, may affect neutralization by some polyclonal and monoclonal antibodies.

P.1 lineage (a.k.a. 20J/501Y.V3): 17 Mutations, The P.1 variant is a branch off the B.1.1.28 lineage that was first reported by the National Institute of Infectious Diseases (NIID) in Japan in four travelers from Brazil, sampled during routine screening at Haneda airport outside Tokyo. The P.1 lineage contains three mutations in the spike protein receptor binding domain: K417T, E484K, and N501Y. There is evidence to suggest that some of the mutations in the P.1 variant may affect its transmissibility and antigenic profile, which may affect the ability of antibodies generated through a previous natural infection or through vaccination to recognize and neutralize the virus.

Some of the potential consequences of emerging variants are the following:

  • Ability to spread more quickly in people: D614G, confers increased ability to spread more quickly than the wild-type SARS-CoV-2. In the laboratory, 614G variants propagate more quickly in human respiratory epithelial cells, outcompeting 614D viruses. There also is epidemiologic evidence that the 614G variant spreads more quickly than viruses without the mutation.
  • Ability to cause either milder or more severe disease in people: B.1.1.7 variant may be associated with an increased risk of death compared to other variants.
  • Ability to evade detection by specific viral diagnostic tests: B.1.1.7 has S gene target failure
  • Decreased susceptibility to therapeutic agents such as monoclonal antibodies. B.1.1.28
  • Ability to evade natural or vaccine-induced immunity: B.1.1.28

Ability to evade vaccine-induced immunity: Once a large population is vaccinated, there will be immune pressure that could favor and accelerate emergence of such variants by selecting for “escape mutants.” There is no evidence that this is occurring, and most experts believe escape mutants are unlikely to emerge because of the nature of the virus.

·        “Wild-type” refers to the strain of virus – or background strain – that contains no major mutations.

Coronavirus Cases:

117,743,532

Deaths:

2,611,697

Recovered:

93,416,309

ACTIVE CASES

21,715,526

Currently Infected Patients

21,625,667 (99.6%)

in Mild Condition

89,859 (0.4%)

Serious or Critical

CLOSED CASES

96,028,006

Cases which had an outcome:

93,416,309 (97%)

Recovered / Discharged

2,611,697 (3%)

Deaths 

#Country,
Other
Total
Cases
New
Cases
Total
Deaths
New
Deaths
Total
Recovered
Active
Cases
Serious,
Critical
Population
World117,743,532+291,5752,611,697+6,40693,416,30921,715,52689,859
1USA29,743,833+44,297538,603+76320,449,4818,755,74913,009332,330,903
2India11,244,624+15,353157,966+7610,897,486189,1728,9441,389,271,622
3Brazil11,055,480+36,136266,614+1,1149,782,3201,006,5468,318213,592,800
4Russia4,333,029+10,25389,473+3793,922,246321,3102,300145,977,387
5UK4,223,232+4,712124,566+653,278,629820,0371,54268,130,111
6France3,909,560+5,32788,933+359266,0963,554,5313,84965,372,513
7Spain3,160,970+4,72171,436+1002,810,929278,6052,47146,767,201
8Italy3,081,368+13,902100,103+3182,508,732472,5332,70060,400,789
9Turkey2,793,632+13,21529,094+642,632,030132,5081,23984,958,667
10Germany2,513,768+5,11372,698

India

8th March: New Cases 15353, New Deaths 76, Total Cases 11244624, Total Deaths 157996, Active Cases 189172

7th March: New Cases 18691, New Deaths 99, Total Cases 11229271, Total Deaths 157890, Active Cases 190501

6th March: New Cases 18716, New Deaths 98, Total Cases 11210580, Total Deaths 157791, Active Cases 186253

5th March: New Cases 18292, New Deaths 109, Total Cases 11191864, Total Deaths 157693, Active Cases 181997

4th March: New Cases 16824, New Deaths 113, Total Cases 11173572, Total Deaths 157584, Active Cases 177967

3rd March: New Cases 17425, New Deaths 86, Total Cases 11156748, Total Deaths 157471, Active Cases 175044

2nd March: New Cases 15704, New Deaths 110, Total Cases 11139323, Total Deaths 157385, Active Cases 171776

1st March: New Cases 10930, New Deaths  62, Total Cases 11122986, Total Deaths 157257, Active Cases 169565

28th February: New Cases 15616, New Deaths 108, Total Cases 11112056, Total Deaths 157195, Active Cases 170293

27th February: New Cases 17346, New Deaths 117, Total Cases 11096440, Total Deaths 157087, Active Cases 166079

26th February: New cases 16056, New Deaths 109, Total Cases 11079094, Total Deaths 156970, Active Cases 160985

25th February: New Cases 16568, New deaths 119, Total Cases 11063038, Total Deaths 156861, Active Cases 157418

24th February: New Cases 17106, New Deaths 144, Total Cases 11046432, Total Deaths 156742, Active Cases 153257

23rd February: New Cases 13463, New Deaths 100, Total Cases 11029326, Total Deaths 156598, Active Cases 148584

22nd February: New Cases 10792, New Deaths 80, Total Cases 11015863. Total Deaths 156498, Active Cases 148882

21st February: New Cases 13980, New Deaths 79, Total Cases 11005071, Total Deaths 156418, Active Cases 151639

20th February: New Cases 14315, New Deaths 99, Total Cases 10991091, Total Deaths 156339, Active Cases 147214

19th February: New Cases 14587, New Deaths 117, Total Cases 10976776, Total Deaths 156240,

18th February: New cases 12643, New Deaths 85, Total Cases 10962189, Total Deaths 156123, Active Cases 140998

17th February: New Cases 12440, New Deaths 89, Total Cases 10949546, Total Deaths 156038, Active Cases 138802

16th February: New Cases 11795, New Deaths 109, Total Cases 10937106, Total Deaths 155949, Active Cases 138254

15th February: New Cases 9139, New Deaths 76, Total Cases 10925311, Total Deaths 155840, Active Cases 138579

14th February: New Cases 11434, New Deaths 91, Total Cases 10916172, Total Deaths 155764, Active Cases 141325

13th February: New Cases 12188, New Deaths 85, Total Cases 10904738, Total Deaths 155673, Active Cases 139277

12th February: New Cases 12137, New Deaths 104, Total Cases 10892550, Total Deaths 155588, Active Cases 138253

11th February: New Cases 9353, New Deaths 85, Total Cases 10880413, Total Deaths 155484, Active Cases 137578

10th February: New Cases 12760, New Deaths 119, Total Cases 10871060, Total Deaths 155399, Active Cases 144032

9th February: New Cases 10510, New Deaths 85, Total Cases 10858300, Total Deaths 155280, Active Cases 143416

8th February: New Cases 8947, New Deaths 81, Total Cases 10847790, Total Deaths 155195, Active Cases 145690

7th February: New Cases 11673, New Deaths 86, Total Cases 10838843, Total Deaths 155114, Active Cases 150653

6th February: New Cases 11948, New Deaths 72, Total Cases 10827170, Total Deaths 155028, Active Cases 150733

5th February: New cases 11689, New Deaths 94, Total Cases 10815222, Total Deaths 154956, Active Cases 150476

4th February: New Cases 12410, New Deaths 120, Total Cases 10803533, Total Deaths 154862, Active Cases 153270

3rd February: New Cases 12917, New Deaths 107, Total Cases 10791123, Total Deaths 154742, Active Cases 156873

2nd February: New Cases 11000, New Deaths 113, Total Cases 10778206, Total Deaths 154635, Active Cases 161865

1st February: New Cases 8587, New Deaths 94, Total Cases 10767206, Total Deaths 154522, Active Cases 165234

31st January: New Cases 11528, New Deaths 116, Total Cases 10758619, Total Deaths 152428, Active Cases 170203

30th January: New Cases 13065, New Deaths 128, Total cases 10747091, Total Deaths 154312, Active Cases 170670

29th January: New cases 13055, New deaths 137, Total Cases 10734026, Total Deaths 154184, Active cases 171968

28th January: New Cases 18940, New Deaths 162, Total Cases 10720971, Total Deaths 154047, Active Cases 173762

27th January: New Cases 11752, New Deaths 134, Total Cases 10702031, Total Deaths 153885, Active Cases 175328

26th January: New Cases 12569, New Deaths 127, Total Cases 10690279, Total Deaths 153751, Active Cases 178200

25th January:  New Cases 9036, New Deaths 116, Total Cases 10677710, Total Deaths 153624, Active Cases 178808

24th January: New Cases 13239, New deaths 132, Total Cases 10668674, Total Deaths 153508, Active Cases 185992

23rd January: New cases 14891, New deaths 155, Total Cases 10655435, Total Deaths 153376, Active Cases 185963

22nd January: New Cases 14344, New Deaths 154, Total Cases 10640544, Total Deaths 153221, Active Cases 187260

21st January: New cases 14481, New Deaths 161, Total Cases 10626200, Total Deaths 153067, Active Cases 190976

20th January: New Cases 15277, New Deaths 152, Total Cases 10611719, Total Deaths 152906, Active Cases 193650

19th January: New Cases 13795, New Deaths 161, Total Cases 10596442, Total Deaths 152754, Active Cases 198596

18th January: New Cases 9975, New Deaths 137, Total Cases 10582647, Total Deaths 152593, Active Cases 202202

17th January: New Cases 13962, New Deaths 145, Total Cases 10572672, Total Deaths 152456, Active Cases 209519

16th January: New Cases 15051, New Deaths 181, Total Cases 10558710, Total Deaths 152311, Active Cases 210215

15th January: New cases 15151, New Deaths 176, Total Cases 10543659, Total Deaths 152130, Active Cases 212646

14th January: New Cases 15677, New Deaths 189, Total Cases 10528508, Total Deaths 151954, Active Cases 214472

13th January: New Cases 17015, New Deaths 201, Total cases 10512831, Total Deaths 151765, Active Cases 214812

12th January: New cases 15903, New Deaths 200, Total Cases 10495816, Total Deaths 151564, Active Cases 217839

11th January: New cases 12482, New Deaths 166, Total Cases 10479913, Total Deaths 151364, Active Cases 217881

10th January: New cases 16085, New Deaths 150, Total cases 10467431, Total Deaths 151198, Active Cases 224103

9th January: New Cases 18820, New Deaths 213, Total Cases 10451346, Total Deaths 151048, Active Cases 224903

8th January: New cases 18482, New deaths 229, Total Cases 10432526, Total Deaths 150835, Active Cases 225756

7th January: New cases 18106, New Deaths 234, Total Cases 10414044, Total Deaths 150606, Active Cases 226716

6th January: New Cases 20460, New Deaths 221, Total Cases 10395938, Total Deaths 150372, Active Cases 229403

5th January: New cases 17909, New Deaths 265, Total Cases 10375478, Total Deaths 150151, Active Cases 228833

4th January: New Cases 16278, New Deaths 200, Total Cases 10357569, Total Deaths 149886, Active Cases 232343

3rd January: New Cases 16660, New Deaths 215, Total Cases 10341291, Total Deaths 149686, Active Cases 245474

2nd January: New Cases 21222, New Deaths 266, Total Cases 10324631, Total Deaths 149471, Active Cases 248633

1st January: New Cases 17080, New Deaths 187, Total Cases 10303409, Total Deaths 149205, Active Cases 252275

31st December: New Cases 19046, New deaths 244, Total Cases 10286329, Total Deaths 149018, Active Cases 255525

30th December: New cases 21957, New deaths 299, Total Cases 10267283, Total Deaths 148774, Active Cases 258747

29th December: New cases 20529, New Deaths 285, Total Cases 10245326, Total Deaths 148475, Active Cases 263512

28th December: New Cases 16072, New Deaths 250, Total Cases 10224797,  Total Deaths 148190, Active Cases  269840

27th December: New Cases 20333, New Deaths 281, Total Cases 10208725, Total Deaths 147940, Active Cases 278840

26th December: New Cases 18574, New Deaths 280, Total Cases 10188392, Total Deaths 147659, Active Cases 279885

25th December: New cases 22350, New Deaths 251, Total Cases 10169818, Total Deaths 147379, Active Cases 283057

24th December: New Cases 23924, New Deaths 350, Total Cases 10147468, Total Deaths 147128, Active Cases 283142

23rd December: New Cases 24236, New Deaths 302, Total Cases 10123544, Total Deaths 146778, Active Cases 284705

22nd December: New Cases 23886, New Deaths 331, Total Cases 10099308, Total Deaths 146476, Active Cases 290130

21st December: New cases 19174, New Deaths 302, Total Cases 10075422, Total Deaths 146145, Active Cases 293663

20th December: New cases 24589, New Deaths 330, Total Cases 10056248, Total Deaths 145843, Active Cases 305015

19th December: New Cases 26834, New Deaths 342, Total Cases 10031659, Total Deaths 145513, Active Cases 306465

18th December:New Cases 26991, New Deaths 342, Total Cases 10004825, Total Deaths 145171, Active Cases 309731

17th December: New cases 26762, New deaths 342, Total Cases 9977834, Total Deaths 144829, Active Cases 312961

16th December: New Cases 18164, New Deaths 357, Total cases 9951072, Total Deaths 144487, Active Cases 328922

15th December: New cases 26401, New Deaths 384, Total Cases 9932908, Total Deaths 144130, Active Cases 332985

14th December: New Cases 21791, New deaths 353, Total Cases 9906507, Total Deaths 143746, Active Cases 340929

13th December: New Cases 27336, New Deaths 338, Total Cases 9884716, Total Deaths 143393, Active Cases  353715

12th December: New Cases 30354, New deaths 393, Total Cases 9857380, Total Deaths 143055, Active Cases 357446

11th December: New cases 30034, Total cases 9827026, New Deaths 440, Total Deaths 142662, Active Cases 360572

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